Diffusion Kurtosis Imaging Combined with Intravoxel Incoherent Motion Imaging in Prediction of P53 Status in Rectal Cancer

Mutant P53 promotes tumor cell proliferation, invasion, and resistance to chemotherapy. The purpose of this study was to evaluate the value of combination of DKI and IVIM for prediction of P53 expression status in rectal cancer. The results indicate that the combination of MK and D* improved the diagnostic efficiency than single parameters. DKI and IVIM imaging allows non-invasive visualization and quantification of tissue composition for prediction of P53 status in rectal cancer.