Prediction for P53 Status Using Intravoxel Incoherent Motion Imaging in Rectal Cancer

Mutant P53 promotes tumor cell proliferation, invasion, and resistance to chemotherapy. The purpose of this study was to evaluate the value of intravoxel incoherent motion (IVIM) imaging for prediction of P53 expression status in rectal cancer. The results indicate that D and f values for positive P53 status were significantly lower than those for negative P53 status, while D* was higher. The combination of D, D* and f improved diagnostic efficiency than single parameters. IVIM imaging allows non-invasive visualization and quantification of tissue composition for prediction of P53 status in rectal cancer.