Neurite orientation dispersion and density MR imaging: discriminating atypical high-grade glioma from primary central nervous system lymphoma

Preoperative differentiation of atypical high-grade glioma (HGG) (with no or little necrosis) and primary central nervous system lymphoma (PCNSL) may help to develop treatment plans. However, they share similar appearance in routine MR images. As a new diffusion model, neurite orientation dispersion and density imaging (NODDI) reflects the microstructure of tissue by measuring different components within it. Through quantitative analysis, we found that all parameters of NODDI performed excellent in distinguishing between atypical HGG and PCNSL.