MRI profiling of temporal lobe epilepsy with hippocampal sclerosis using multi-compartment diffusion models

The hippocampal microstructural alterations by using routine magnetic resonance imaging presents a challenge. This study aimed to evaluate the performance of the NODDI and MAP models in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS). Our results found that all NODDI and MAP parameters had significant differences between ipsilateral HS and contralateral HS/HC, and had MAP models better diagnostic performance than NODDI. In addition, combined MAP model had significant better diagnostic performance than all the single parameters. In conclusion, MAP is superior to NODDI in diagnosing TLE with HS.