White matter integrity and structural connectivity disruption in cognitive impairment T2DM patients with cerebral small vessel disease

DTI provides an effective way to investigate the white matter integrity and white matter connectivity. In this study, almost the white matter integrity was injured in cognitive impairment T2DM patients with CSVD, which were accompanied with reduction of FA value and increasing of λ∥、λ⊥ and ADC values. These results suggested that axonal injuries and demyelinating diseases maybe exist and induce the network connectivity disruption in these patients. More over, In patients with T2DM, network parameters were associated with memory and attention, significantly correlation were found between network parameters and cognitive assessment scores. These findings may provide new insights into how white matter abnormalities and white matter network disruption can affect cognitive function in patients with diabetes.