Application of diffusion imaging and dynamic contrast-enhanced MRI in evaluating the proliferation status of endometrial carcinoma

Intravoxel incoherent motion (IVIM) is able to reflect the true diffusion, microcirculatory perfusion, average diffusion, and structural complexity in tissues. Dynamic contrast-enhanced MRI (DCE-MRI) can be used to analyze the dynamic distribution of contrast agents through the pharmacokinetic model to quantitatively detect the blood supply of biological tissues. Our results showed that IVIM and DCE-MRI-derived parameters such as D, α, Ktrans, and Kep were associated with Ki-67 status in EC, and the combination of D and Kep may serve as a superior imaging marker for the identification of low-proliferation and high-proliferation EC.