Detection of Lesions in Focal Epilepsy by Asymmetry Analysis of MR Fingerprinting

Conventional MRI is limited in diagnosis of subtle epileptic lesions. Therefore, this study aimed to localize epileptic lesions by using MRF technology. Twenty epilepsy patients were included which underwent T1, T2 and MRF examinations. The MRI were spatially normalized to the symmetric ICBM-152 template, followed by transformation of T1 and T2 MRF maps. Absolute asymmetric index (|AI|) analysis was then performed on T1 and T2 MRF maps to detect epileptic lesions. Results showed that the |AI| analysis can detect epileptogenic foci in 75% of patients. In conclusion, the asymmetry analysis could help improve epileptic focus localization in clinical practice.