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Imaging lactic acidosis is of significance for injury assessment in acute stroke. In this study, we investigated the progression of lactate, along with the concomitant changes in N-acetylaspartate and creatine concentrations, and its relationship to infarct growth using high-resolution MRSI data acquired from a longitudinal cohort of 42 ischemic stroke patients. The results showed that the progression in lactate level was predictive of infarct growth volume from acute to subacute stroke. Our study might provide a useful biomarker for lactic acidosis and tissue injury assessment in ischemic stroke.
Bo et al. (Wed,) studied this question.
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