Comparison of Myelin Water Imaging from Multi-echo T2 Decay Curve and Myelin Content from Synthetic MRI

Imaging myelin has long been a target in neuroimaging. Several MR techniques have been developed for in vivo measurement of myelin content. Myelin water fraction (MWF) from multi-echo T2 decay curve has been shown to be a reliable marker for myelin. Myelin content using quantitative synthetic MRI (SyMRI) has also been used to quantify myelin in the brain. In this work, we performed 3D GRASE and SyMRI (using multi-contrast 3D gradient echo) to estimate the myelin correlations between these two techniques. This work will provide guidance for future studies using myelin imaging techniques.