Multisite Intravoxel Incoherent Motion Repeatability and Reproducibility in a Breast Diffusion Phantom at 3T

Monoexponential apparent diffusion coefficient (ADC) and biexponential intravoxel incoherent motion (IVIM) analysis of diffusion-weighted imaging (DWI) is helpful in the characterization of breast tumors. Toward this goal, a novel breast phantom containing tubes of different polyvinylpyrrolidone (PVP) concentrations, water, fat, and sponge flow chambers was utilized. This work tests this breast phantom at two sites employing different vendor MRI scanners to estimate the ADC and IVIM parameters. The results are reproducible within sites, and show progress towards reproducibility across sites and vendors, and can be used in the future in multicenter clinical trials for breast cancer characterization, prediction and prognosis.