3D mTI-ASL perfusion for differentiating 1p/19q status in IDH1-mutant lower grade gliomas

This study investigated the feasibility of using local maximum cerebral blood flow (maxCBF) in tumor area measured with multi-inversion-time ASL (mTI-ASL) to preoperatively predict the 1p/19q status in patients with IDH1-mutant lower-grade glioma (LGG). Mann-Whitney U test showed that maxCBF in the tumor region was significantly higher in 1p/19q Non-Codeleted group than Codeleted group. ROC showed maxCBF achieved high sensitivity (0.7) and specificity (0.737) in differentiation of IDH1-mutant-LGGs with distinct 1p/19q status. This finding suggested that ASL-derived maxCBF has the potential as a tool for the noninvasive preoperative characterization of 1p/19q status, thus providing evidence for individualized treatment planning.