Role of Epigenetic Modifications and HDAC Inhibitors in Glioblastoma Multiforme (GBM)

Glioblastoma Multiforme (GBM) is one of the most formidable forms of brain tumors due to its highly aggressive nature, rapid proliferation, and resistance to conventional therapies. Histone deacetylases (HDACs) regulate chromatin structure and gene expression, and they have been associated with the silencing of tumor suppressor genes and promotion of cell survival. Although HDAC inhibition has shown some promise in preclinical studies, the specific mechanisms through which HDACs influence GBM cell behavior and the most effective strategies for HDAC inhibition remain poorly understood. There is a lack of research surrounding the optimal conditions for therapeutic efficiency of HDACs for cancer and a lack of comprehensive understanding of how HDACs impact GBM cell proliferation, survival, and gene expression.There is a lack of comprehensive understanding regarding how inhibiting HDACs impacts GBM cell proliferation, survival, and gene expression, as well as the optimal conditions for therapeutic efficacy.