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RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction | Synapse

August 1, 2024Open Access

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RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction

KHKeiko HikinoRIKEN SKSatoshi KoyamaBroad Institute KIKaoru ItoChiba University

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Resumen

Vasospastic angina (VSA) is vasospasm of the coronary artery and is particularly prevalent in East Asian populations. However, the specific genetic architecture for VSA at genome-wide levels is not fully understood.

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Hikino et al. (Thu,) studied this question.

synapsesocial.com/papers/68e5dc4ab6db643587571ac4 https://doi.org/https://doi.org/10.1001/jamacardio.2024.1483

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Clinical Characteristics and Long-Term Prognosis of Vasospastic Angina Patients Who Survived Out-of-Hospital Cardiac Arrest2011 · 189 citations
2Role of Autonomic Nervous System in the Pathogenesis of Prinzmetal's Variant Form of Angina1974 · 459 citations
3Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm.1986 · 551 citations
42014 Williams Harvey Lecture: importance of coronary vasomotion abnormalities--from bench to bedside2014 · 228 citations
5Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients2013 · 127 citations