Hedgehog/Gli2 signaling triggers cell proliferation and metastasis via EMT and Wnt/β-catenin pathways in oral squamous cell carcinoma1

Oral squamous cell carcinoma (OSCC) is the most lethal oral malignant tumor, however, clinical outcomes remain unsatisfactory. The Hedgehog/Gli2 pathway plays a pivotal role in tumor progression, yet the regulatory mechanism governing its involvement in the malignant evolution process of OSCC remains elusive.