Evaluation of Immunohistochemical Expression of p53 in Colorectal Carcinoma

major cause of morbidity and mortality. In colorectal carcinoma the most frequently mutated geneis p53 tumor suppressor gene. Mutation of p53 gene gives rise to abnormal protein which can beeasily detected by immunohistochemistry. Expression of mutant p53 protein has been associatedwith poor clinical outcome and increased risk of death due to increased aggressiveness of thedisease.Objective: The aim of the study was to see the clinicopathological correlation of mutant p53expression in colorectal carcinoma.Method: Total 50 paraffin embedded tissue blocks of histopathologically diagnosed cases ofcolorectal cancer were evaluated by immunohistochemical staining for mutant p53 expression. Thestudy was performed in Sir Salimullah Medical College, Dhaka (from March, 2018 to February,2020).Results: Out of 50 patients studied, 29 cases (58%) expressed mutant p53 protein in the nucleus ofmalignant cells. There was significant association between p53 protein expression andclinicopathologic variables such as age (40 years, p=0.032), site of tumor (left vsright colon, p=0.028), pathological type (mucinous vs non mucinous, p=0.039), grade (a greatertendency towards poor differentiation, p= 0.039), advanced stage (both TNM and Dukes), whereasno significant association was found between mutant p53 protien expression and other parameterslike gender and morphological types.Conclusion: The results of this current study revealed that mutant p53 positive colorectal cancertended to be related to a higher grade of malignancy, advanced tumor stage and mucinousmorphology. The results of this current study revealed that mutant p53 positive colorectal cancertended to be related to a higher grade of malignancy, advanced tumor stage and mucinousmorphology. So, p53 is an important immunohistochemical marker for colorectal cancer patients.