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July 17, 2024

Sotorasib for Vascular Malformations Associated with KRAS G12C Mutation

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Resumen

gain-of-function mutations are frequently observed in sporadic arteriovenous malformations. The mechanisms underlying the progression of such

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Cite This Study

Fraissenon et al. (Wed,) studied this question.

synapsesocial.com/papers/68e5fef1b6db643587592d1c https://doi.org/https://doi.org/10.1056/nejmoa2309160

Sotorasib for Vascular Malformations Associated with KRAS G12C Mutation | Synapse

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3Genomic Instability and Cancer2014 · 227 citations
4Trametinib as a promising therapeutic option in alleviating vascular defects in an endothelial KRAS-induced mouse model2022 · 42 citations
5Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling2020 · 133 citations