Effect of Hemoglobinopathy on Maternal and Fetal Outcome: Single Center Study

Background and aim: Hemoglobinopathies pose to be a major risk factor for pregnancy leading to potentially fatal maternal and neonatal complications.The aim of our study was to compare maternal and neonatal outcomes of pregnancy in women with a hemoglobinopathy and without a hemoglobinopathy. Materials and methods:The present study is a comparative retrospective analysis of 153 pregnant women with hemoglobinopathies and 153 pregnant women without hemoglobinopathies who were treated between June 2020 and May 2023, in Dhiraj Hospital,Vadodara.We analyzed various data regarding maternal as well as neonatal outcomes and complications in hemoglobinopathies.Results: Among the maternal outcomes, the rate of previous miscarriage, intrauterine growth restriction (IUGR), postpartum hemorrhage (PPH), and anemia were significantly increased in women with hemoglobinopathies.Among the neonatal outcomes, the rate of anemia and low birth weight were significantly increased in all type of hemoglobinopathic pregnancies.Hepatic encephalopathy, septicemia, jaundice, perinatal death, and fetal acidosis were also increased in sickle cell disease (SCD) pregnancies. Conclusion:It is pivotal to supervise pregnancies with hemoglobinopathies for minimal morbidity and mortality in mother as well as fetus.Timely multispecialty intervention can help in improving the fetomaternal outcomes.