Comparison Study of Some Antibiotics Sensitivity among Staphylococcus aureus and Coagulase-negative Staphylococci

Every year, hundreds of thousands of fatalities are brought on by bacteria that have developed widespread antibiotic resistance.The most important issue is the number of bacteria that are becoming more resistant to widely used antibiotics. 1,2 All types of therapeutically used antibiotics have inactivity against staphylococcus species.The majority of antibiotics used to treat staphylococcal infections target key bacterial functions such as DNA synthesis, translation, transcription, and cell wall formation. 3,4 Antibiotic resistance, however, is an issue that is becoming worse, and unsuccessful treatments have high consequences in terms of both money and lives.There are several processes by which antibiotic resistance developed. 5,6 In the current study, a total of 60 staphylococcus species were isolated clinically from patients in different sites.Gram stain, colony morphology on blood agar, and biochemical tests were done for microbial identification.After growth on culture media, a subculture on mannitol salt agar (HIMEDIA, India) was done for all isolates.The are 30 isolates Staphylococcus aureus and 30 isolates coagulase-negative staphylococci (CoNS).Meropenem showed low resistance for staphylococcus isolates 16.7% followed by both levofloxacin and azithromycin 43.3%.Staphylococcus spp were 63.3 and 73% resistant to ceftazidime and fosfomycin respectively.Staphylococcus spp.showed high resistance to aztreonam at 96% (Fig. 1).Staphylococcus aureus showed high resistance to levofloxacin at 76.7% compared to CoNS at 43.3% significantly (p 0.05) (Table 1).To conclude, levofloxacin and azithromycin are more effective against CoNS than S. aureus significantly (p < 0.05).Due to increasing resistance to staphylococcus species, a line of new