Endoplasmic reticulum and mitochondrial calcium handling dynamically shape slow afterhyperpolarizations in vasopressin magnocellular neurons

Many neurons including vasopressin (VP) magnocellular neurosecretory cells (MNCs) of the hypothalamic supraoptic nucleus (SON) generate afterhyperpolarizations (AHPs) during spiking to slow firing, a phenomenon known as spike frequency adaptation. The AHP is underlain by Ca