Systematic Review on: Breast Cancer and its Relationship with Prolonged Use of Combined Oral Contraceptives

Introduction: Breast cancer is a neoplasm in breast tissues, diagnosed in 1 in 8 women, making it one of the most common cancers in the female population. Objective: To analyze the relationship between the constant use of oral contraceptives and the risk of developing breast cancer. Methodology: A systematic review was conducted using the Prisma method, utilizing PubMed and SCOPUS, selecting 14 relevant articles. Results: The reviewed studies showed variable results. Some studies with small samples found some association, while studies with larger populations did not confirm this relationship. Prolonged use of oral contraceptives was associated with a higher risk in young women. Factors such as advanced age at first childbirth and smoking also increased the risk. Most studies highlighted prolonged use (5 to 10 years) as a potential risk, along with modifiable factors like smoking and obesity. Discussion: Although some studies suggest a possible association between oral contraceptives and breast cancer, the results are inconclusive. Additional factors complicate interpretation. Conclusion: More research with large populations is needed to better understand the relationship between oral contraceptives and breast cancer.