188-OR: Association of Social Determinants of Health with Efficacy of Metabolic Bariatric Surgery (MBS) vs. Medical Therapy (MT) for Type 2 Diabetes

Introduction u/u7 year follow-up, 169 (65%) completed the survey; completers did not differ from noncompleters for age, sex, or race. SDOH measures did not differ between groups after adjusting for study site. In cross-sectional analyses (end-of-study), scores indicating higher deprivation or food insecurity, lower medication adherence, 0.001), BRIEF (p=0.02), MMAS4 (p0.001), this was greater in MLI (p=0.008) and remained after adjustment for baseline weight and site (p=0.002). Conclusion: Individuals with higher deprivation indices at randomization had less weight loss over time. These associations were stronger for the MLI group, suggesting SDOH may exert greater adverse impact when ongoing need for anti-diabetes medical therapy is greater. Disclosure M. Patti: Research Support; Dexcom, Inc. Consultant; Hanmi Pharm. Co., Ltd., MBX Biosciences. Other Relationship; Fractyl Health, Inc. Consultant; AstraZeneca, Spruce Biosciences. B. Hu: None. H. Wang: None. Y. Sarig: None. D.C. Simonson: Stock/Shareholder; Phase V Technologies, Inc. Advisory Panel; GI Windows. K. Foster: None. D. Wolfs: None. D. Arterburn: None. M.J. O'Brien: None. A.H. Vernon: None. J.M. Jakicic: Research Support; Epitomee. Advisory Panel; Wondr Health. Consultant; Education Initiatives, Inc. S.R. Kashyap: Research Support; Fractyl Health, Inc. Advisory Panel; GI Dynamics. Research Support; Janssen Pharmaceuticals, Inc. A. Aminian: Research Support; Medtronic. Consultant; Medtronic, Ethicon, Inc. Research Support; Ethicon, Inc. Advisory Panel; Eli Lilly and Company. P. Schauer: Research Support; Ethicon, Inc. Other Relationship; Ethicon, Inc. Research Support; Medtronic. Other Relationship; Medtronic, Novo Nordisk. Advisory Panel; Lilly Diabetes, GI Dynamics, Heron. Stock/Shareholder; Mediflix, SE Healthcare. Other Relationship; Klens. Advisory Panel; Persona, Keyron. Stock/Shareholder; Metabolic Health International LTD. D.E. Cummings: None. W.F. Gourash: None. A. Courcoulas: Research Support; Allurion, Eli Lilly and Company. J.P. Kirwan: None. Funding National Institutes of Health (U01 DK114156)