77-OR: Time in Range Is Associated with Glucagon/C-Peptide Index Ratio in Type 2 Diabetes Patients

Introduction 45 ml/min/1.73 m2 of eGFR were excluded. We analyzed the data obtained from CGM, including time in range (TIR), time below range (TBR), time above range (TAR), average glucose (AVG), and standard deviation of glucose (SD), and the ratio of plasma glucagon level to C-peptide index (G-CPIR) before and after meal tolerance test or other metabolic factors. Results: Postprandial G-CPIR was inversely correlated with TIR (r = -0.230, P = 0.009), correlated with TAR (r = 0.234, P = 0.014), and AVG (r = 0.251, P = 0.006). Upon comparing the CGM data between the group with high postprandial G-CPIR (HG group) and low G-CPIR (LG group), divided using the median values, TIR was significantly lower (62.4±21.5 vs. 78.5±18.8, P = 0.0053), AVG (166.7±33.5 vs. 145.5±27.9, P = 0.0153) and SD (46.2±14.3 vs. 38.2±11.8, P = 0.0310) were higher than those in LG group. Body fat mass was inversely correlated with SD (r = -0.448, P = 0.014), and subcutaneous fat area (SFA) and visceral fat area (VFA) were correlated with TIR (SFA: r = 0.339, P = 0.006, VFA: r = 0.310, P = 0.032), inversely correlated with TAR (SFA: r = -0.326, P = 0.010, VFA: r = -0.298, P = 0.040) and SD (SFA: r = -0.411, P = 0.001, VFA: r = -0.454, P = 0.001). Conclusion: Our study suggests that CGM indicators, including TIR, are associated with the functional balance of pancreatic alpha to beta cells and body fat mass. Disclosure M. Kamigishi: None. D. Chujo: Research Support; Kyowa Kirin Co., Ltd. A. Takikawa: None. S. Inagawa: None. A. Enkaku: None. S. Ohgaku: None. A. Sato: None. S. Matsukoshi: None. H. Honoki: None. S. Fujisaka: None. K. Tobe: None.