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Gene count normalization in single-cell imaging-based spatially resolved transcriptomics | Synapse

June 12, 2024Open Access

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Gene count normalization in single-cell imaging-based spatially resolved transcriptomics

LALyla AttaJohns Hopkins University KCKalen CliftonJohns Hopkins University MAManjari AnantJohns Hopkins University

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Recent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted genes and their locations in fixed tissues. Normalization of gene expression data is often needed to account for technical factors that may confound underlying biological signals.

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Atta et al. (Wed,) studied this question.

synapsesocial.com/papers/68e64f8fb6db6435875e08be https://doi.org/https://doi.org/10.1186/s13059-024-03303-w

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