Supplementary Figure S15 from Safety and Preliminary Efficacy of Pembrolizumab Following Transarterial Chemoembolization for Hepatocellular Carcinoma: The PETAL Phase Ib Study

Supplementary Figure S15. Heatmaps representing the normalised concentration of the metabolites and the metabolite ratios significantly represented across timepoints (A) and across responders and non-responders (B). Normalisation was performed using the sample with highest metabolite concentration from each row as reference (100%). The complete list of metabolites analysed can be found in Suppl.Tab.5. Abbreviations: EOT, End of Treatment; 12w, 12 weeks; Tyr/Phe, Tyrosine/Phenylalanine; Met-SO/Met, Methionine-sulfoxide/Methionine; AC-DC, acylcarnitine derivative of a dicarboxylic acid.