Ab0858 Prevalence and Significance of Nailfold Capillaroscopy Abnormalities in Primary Sjogren’s Syndrome Compared to Primary Raynaud Phenomenon

Background: Raynaud's phenomenon (RP) is known to coexist in 13-30% of patients with primary Sjogren's syndrome (pSS). Studies on findings of nailfold capillaroscopy (NFC) in pSS are limited. Objectives: This single-center, retrospective study aimed to 1) evaluate the NFC features compared to primary RP, and 2) analyze the association between microvascular abnormalities and clinical features in patients with pSS. Methods: We included patients with pSS who fulfilled the 2016 ACR/EULAR classification criteria and patients with primary RP who underwent NFC between 2016 and 2022. Clinical manifestations, laboratory findings, pulmonary function tests, and chest computed tomography findings were collected for each patient, and they were observed until the last follow-up or death. NFC findings were classified into three groups according to the fast track algorithm proposed by the EULAR Study Group: normal, non-specific abnormalities, and scleroderma pattern. Results: A total of 223 patients were included: pSS (n=140), and primary RP (n=83). RP in pSS was observed in 35 patients (25%). Patients with pSS showed significantly more non-specific abnormalities (50.7% vs. 32.5%) and scleroderma pattern (7.8% vs. 0%) than those with primary RP (pppppppppConclusion: Microvascular abnormalities were more common in patients with pSS compared to those with primary RP. pSS patients with microvascular abnormalities had more RP, anti-Ro52, ILD, and impaired lung function. REFERENCES: 1 Smith V, Vanhaecke A, Herrick AL, et al. Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern". Autoimmunity reviews 2019;18:102394. Acknowledgements: NIL. Disclosure of Interests: None declared.