Bioactive phytochemicals and associated multifunctional health-promoting effects of Polygonati Rhizoma

Polygonati Rhizoma, a functional food and a traditional Chinese medicine broadly used in China and several Southeast Asia countries, possesses effective health-promoting activities. Prepared from three plants in Polygonatum family (P. kingianum, P. sibiricum, and P. cyrtonema), Polygonati Rhizoma has drawn increasing attention due to its remarkable immune-enhancing and metabolic regulatory activities in recent years. In this review, we summarized the updated research of chemical constituents and biological activities of Polygonati Rhizoma, especially the metabolic regulation, immunomodulatory effects, and anti-fatigue activities, aiming to provide a comprehensive understanding, broaden the usage and promote more in-depth exploration of Polygonati Rhizoma as a functional food.