Evaluation of liver function enzymes in Hepatitis A, B, and C in children in Ramadi city

Background: Hepatitis A (HAV), B (HBV), C (HCV), D (HDV), and E (HEV) are the leading causes of worldwide liver disease. Acute viral hepatitis (AVH) is a significant public health concern, especially in children from developing countries with inadequate sanitation and water. Chronic HBV infection causes a large number of liver disease fatalities globally. Pediatric HCV and HDV prevalence statistics are scarce.Material and methods: In this study, we conducted a retrospective analysis of 127 children from the AL-Anbar government to assess the prevalence of different types of viral hepatitis. Blood samples were collected from children aged 6 months to 15 years, and comprehensive diagnostic tests were performed, including biochemical analysis and rapid tests for IgM and IgG detection. ELISA was used to provide accurate and reliable results for diagnosis.Results: The study revealed a high prevalence of hepatitis A, B, and C among the enrolled children, with hepatitis A being the most common. Abdominal pain, jaundice, and fever were the predominant symptoms observed. Notably, 50% of children with HBV infection also tested positive for HDV-Ag. However, no cases of HEV infection were detected. Comparative analysis of liver function markers showed significantly higher levels of AST-GOT, ALT-GPT, GGT, ALP, total bilirubin, and direct bilirubin in HCV patients compared to those with HAV and HBV infections.