Types of thromboembolic events and their outcomes among patients with active colorectal cancer: A nationwide propensity matched analysis.

e15530 Background: Venous thromboembolic events (VTE) are a major cause of morbidity & mortality in patients with active cancer. We aim to investigate the outcome and incidence of acute DVT and PE in colorectal cancer compared to all other malignancies. Methods: The National Readmission Database (2016-2020) was queried to identify all-cause admissions for patients with active colorectal cancer (CRC). A Propensity Score Matching (PSM) model, matched such patients with cases having any type of other malignancies. Pearson’s x2 test was applied to the PSM-2 matched cohorts to compare outcomes. Results: Among 2. 9 million all-cause hospitalizations of CRC patients, about 3. 9% suffered a VTE. The majority had acute DVT (1. 9%), followed by acute PE (1. 3%), followed by DVT with PE (0. 7%). After propensity-matching & multivariate analysis, patients with CRC have a lower incidence of acute DVT (2. 7% vs 2. 8%, aOR: 0. 92), acute PE (1. 8% vs 2%, aOR: 0. 84) & DVT with PE (0. 96% vs 1. 02%, aOR: 0. 90) p < 0. 001 as compared to other malignancies. Among different VTEs, the mortality was highest for acute PE (aOR: 2. 66), followed by DVT with PE (aOR: 2. 28) & DVT (aOR: 1. 89) p < 0. 001. Resource utilization is also higher in CRC-related hospitalizations complicated by VTE, with patients suffering a DVT having the highest LOS (9 vs 5 days) & total cost of hospitalization (25, 910 vs 17, 964) p < 0. 001 followed by DVT with PE and PE respectively. CRC patients had higher readmission rates for DVT as compared to PE at 30 days (18. 2% vs 17%, p: 0. 029) and subsequently at 90-day intervals. Conclusions: CRC-related hospitalizations had lower rates of DVT and PE compared to other active malignancies. The mortality was highest for PE in this cohort, while healthcare-related burden and readmission rates were higher for DVT.