Biochemical alternation caused by bovine respiratory disease and ceftiofur

The most prevalent and dangerous disease in herds that raise calves is bovine respiratory disease (BRD). Ceftiofur, third-generation cephalosporin antibiotic, has been approved for use in cattle in the United States. This study was done to investigate the biochemical alternation of the BRD and the effectiveness of ceftiofur. Thirty Holstein calves in a dairy farm were divided in to 3 groups. Group I was utilized as a healthy negative group. Group II was composed of healthy animals injected with ceftiofur (2mg/kg B.W) subcutaneously in the ear as single dose. Group III, clinically investigated to be suffering from BRD, was given ceftiofur with the same dose and administration route as group II. All groups were clinically evaluated at day 0, 7, and 14 after drug administration for illness score, Biochemical analysis showed significant (P