Formulation Development and Optimization of Orodispersible Tablet of Loratadine

Loratadine, a histamine H1 receptor antagonist, is used to treat urticaria and allergic rhinitis. Children who have trouble swallowing tablets make it difficult to administer loratadine orally. F1-F9 batches of Loratadine Tablets (ODTs) 10 mg dose were developed and tested in the present research. In this research, super disintegrants such as croscarmellose sodium, sodium starch glycolate, and crosspovidone were used to manufacture fast-dissolving tablets utilising the direct compression method. In phosphate buffer pH 6.8, the impact of various super disintegrants on tablet dissolving behaviour was examined.