Comparative Network Pharmacology of Artificial Sweeteners to Understand Its Health Consequences

toxicity.Despite safety evaluations, several studies suggest potential health risks associated with chronic consumption of ASwt.A WHO systematic review 3 revealed that replacement of ASwt with sugar does not provide a means for weight management in the long-term, and several studies have discovered a positive correlation between long term ASwt consumption and risk of developing cardiovascular disease 5,8, type 2 diabetes mellitus 6,8,11, and mortality in adults 6,8,9,12.Current literature also reveals other concerning associations between ASwt consumption and various routinely observed clinical conditions, including heightened risks of developing cancer 13,15, chronic kidney disease 16,17, adiposity related diseases 8,9,18,19, as well as non-alcoholic fatty liver disease 20.The adverse effects following chronic intake of ASwt can be consequence to disruptions to insulin signalling and gut microbiota, potentially influencing blood sugar control, impacting digestion, nutrient absorption, overall gut health and increasing the risk of metabolic syndrome 21,22.Despite these reported clinical associations, there is substantial research gap regarding the pharmacodynamic effects of these sweeteners in