Unlocking the Enigma: Systemic Lupus Erythematosus, Pancreatitis, and Pleural Effusion

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a wide range of clinical manifestations due to its potential to affect multiple organ systems. While joint pain, skin rashes, and renal involvement are among the most common presentations, SLE can occasionally manifest in more atypical ways. Acute pancreatitis (AP) and massive pleural effusion, although rare, are potential complications of SLE. This case report highlights the unique presentation of a 33-year-old female presented with AP concurrent with a massive pleural effusion, later diagnosed with SLE. The aim of this report is to shed light on this unusual combination of symptoms in SLE patients and to emphasize the importance of a comprehensive clinical approach in the diagnosis and management of such cases.