Merkel-cell carcinoma: ESMO–EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up

•This ESMO Clinical Practice Guideline provides key recommendations for managing Merkel-cell carcinoma (MCC).•Recommendations are based on available scientific data and the multidisciplinary group of experts' collective opinion.•The guideline covers clinical and pathological diagnosis, staging and risk assessment, treatment and follow-up.•Algorithms for the management of locoregional and inoperable/metastatic disease are provided.•A multidisciplinary team with a high level of expertise in MCC should diagnose and make decisions about therapy.