TFA-Mediated Synthesis of 1,2,4-Oxadiazoles from Carbamates and Nitriles

An unprecedented protocol for the synthesis of 1,2,4-oxadiazoles from carbamates has been developed by employing nitriles as both substrates and solvents. This one-pot procedure achieves the formation of C═N bonds via TFA-mediated 3+2 annulation. A series of 1,2,4-oxadiazoles are synthesized in moderate to good yields.