April 22, 2024Open Access

Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease

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Resumen

We investigated the association between white matter hyperintensities (WMH) and regional cortical thickness, amyloid and tau deposition, and synaptic density in the WMH-connected cortex using multimodal images.

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Zhang et al. (Mon,) studied this question.

synapsesocial.com/papers/68e6e0a4b6db64358765ca19 https://doi.org/https://doi.org/10.1002/alz.13845

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1The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis2010 · 2,321 citations
2How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging2003 · 3,749 citations
3Posterior white matter disease distribution as a predictor of amyloid angiopathy2014 · 119 citations
4White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies2023 · 29 citations
5White matter hyperintensities in Alzheimer's disease: Beyond vascular contribution2023 · 125 citations

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