0966 Mood in OSA Patients with Different Chronotypes with and Without Chronic Pain

Abstract Introduction Mood has been related to chronotype, OSA and pain, although no studies have examined these three variables simultaneously. This study analyzes depression symptoms in relationship to self-reported sleep timing, PSG-determined AHI and the presence of chronic pain conditions (CPC) in patients referred for OSA evaluation. Methods From patients tested between 08/2017 and 04/2021, 360 (210 women) were selected based on self-reported sleep time criteria, no shift work, no significant cardiac, pulmonary, neurological, endocrine or psychiatric history except depression/anxiety; 78 had CPC (e.g., fibromyalgia, arthritis, sciatica, musculoskeletal pain and similar). Self-reported sleep times defined typical chronotype (TC, asleep 10pm-12am, wake-up 6-9am), early and late chronotypes (EC, LC, earlier or later than TC); those not clearly meeting these criteria or reporting 6hr or 10hr of usual sleep were excluded. The Center for Epidemiologic Studies Depression Scale-Revised (CESDR) was an outcome; explanatory variables were AHI, chronotypes (EC, TC, LC), CPC; covariates were age, sex, BMI. Results EC (n=115), TC (n=163) and LC (n=82) were unrelated to CPC (chi-square=1.1, p=0.58). Older age (M=48.5±15.7) was predictive of lower CESDR (F=17.5, p 0.001). AHI (M=14.6±21.0) was unrelated to CESDR (F=1.6, p=0.21) and did not interact with CPC or chronotypes. CPC presence predicted higher CESDR (F=8.1, p=0.004). Chronotypes predicted CESDR (F=7.8, p 0.001) without significant interaction with CPC. LC/CPC-absent group had higher CESDR (M=20.7±18.9) relative to EC/CPC-absent (M=11.5±11.3, p 0.001) and TC/CPC-absent (M=10.1±10.6, p 0.001, Bonferroni post-hoc). Among CPC-present patients, CESDR did not significantly differ between EC (M=17.5±14.5), TC (M=16.3±10.3) and LC (M=22.9±17.3). Conclusion In this sample, there was no relationship between OSA and depression symptoms. In patients without CPC, late self-reported sleep time was associated with higher depression symptoms, relative to early and typical sleep times. However, in patients with CPC, CESDR scores did not reach significant difference between chronotypes, apparently due to the overall elevation of depression symptoms in these patients. Support (if any) none