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Late-Stage Saturation of Drug Molecules | Synapse

April 15, 2024Open Access

Late-Stage Saturation of Drug Molecules

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Resumen

The available methods of chemical synthesis have arguably contributed to the prevalence of aromatic rings, such as benzene, toluene, xylene, or pyridine, in modern pharmaceuticals. Many such sp

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Cite This Study

Liu et al. (Mon,) studied this question.

synapsesocial.com/papers/68e6f047b6db64358766ad15 https://doi.org/https://doi.org/10.1021/jacs.4c00807

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Borane-Catalyzed Transfer Hydrogenations of Pyridines with Ammonia Borane2016 · 90 citations
2The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?2009 · 896 citations
3Effects of 1-cyclohexyl- and 1-cyclohexyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline on dopaminergic spontaneous discharge in nigral neurons of rats2016 · 4 citations
4α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment2020 · 606 citations
5Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success2009 · 4,397 citations