PD61-07 THE COMPREHENSIVE 6-MONTH PROSTATE CANCER-PATIENT EMPOWERMENT PROGRAM (PC-PEP) IMPROVES URINARY FUNCTION AMONG MEN WITH PROSTATE CANCER: PRELIMINARY RESULTS OF a PHASE 4 PAN-CANADIAN AND INTERNATIONAL IMPLEMENTATION TRIAL

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy IV (PD61)1 May 2024PD61-07 THE COMPREHENSIVE 6-MONTH PROSTATE CANCER-PATIENT EMPOWERMENT PROGRAM (PC-PEP) IMPROVES URINARY FUNCTION AMONG MEN WITH PROSTATE CANCER: PRELIMINARY RESULTS OF a PHASE 4 PAN-CANADIAN AND INTERNATIONAL IMPLEMENTATION TRIAL Charlie Gillis, Gabriela Ilie, Cody MacDonald, Ross Mason, Ricardo Rendon, Nikhilesh Patel, David Bowes, Greg Bailly, David Bell, Derek Wilke, and Robert Rutledge Charlie GillisCharlie Gillis , Gabriela IlieGabriela Ilie , Cody MacDonaldCody MacDonald , Ross MasonRoss Mason , Ricardo RendonRicardo Rendon , Nikhilesh PatelNikhilesh Patel , David BowesDavid Bowes , Greg BaillyGreg Bailly , David BellDavid Bell , Derek WilkeDerek Wilke , and Robert RutledgeRobert Rutledge View All Author Informationhttps://doi.org/10.1097/01.JU.0001009352.31737.3d.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The Prostate Cancer-Patient Empowerment Program was found to be effective in improving urinary symptoms for patients undergoing primary treatment for localized prostate cancer. This implementation trial seeks to determine the effects of the PC-PEP intervention in patients who are at various stages in their prostate cancer management. METHODS: 186 men with a variety of treatments for localized and metastatic prostate cancer were enrolled in PC-PEP, an online, comprehensive patient resource comprising physical, mental, and social support. Daily emails or texts reminded men to follow the program's PFMT videos 3 times per day. Videos included relaxation, quick-twitch and endurance exercises. Patients then completed weekly online compliance surveys and the International Prostate Symptom Score (IPSS) questionnaire at baseline and six months. RESULTS: Demographic characteristics are presented in Table 1. On average, the PC-PEP group reported performing PFMT 3.5 times per day (3 times a day was prescribed). Overall, men who received the PC-PEP intervention had significantly improved IPSS sum score when compared to baseline (mean IPSS difference 1.56 (95% CI 0.52–2.60, p=0.003). Urinary function was better than baseline among the 107 patients who had received radical prostatectomy (mean IPSS difference 1.94 (95% CI 0.40–3.50, p=0.014), and the 73 patients who were treated with radiation (either beam or brachy), mean IPSS difference 1.7 (95% CI 0.31–3.09, p=0.017. Men on active surveillance or hormone therapy only, showed comparable urinary function from pre- to post-intervention (p=0.19 and p=0.11, respectively). Patients who received salvage radiation had improved urinary function, mean IPSS difference 4.46 (95% CI 1.80–7.13, p<0.002). CONCLUSIONS: PC-PEP appears to significantly improve urinary tract symptoms in prostate cancer patients who are in various stages of disease treatment. Patients who underwent salvage radiotherapy may derive the most benefit. These findings add to our previous RCT results showing that PC-PEP significantly improves urinary function among men with curative disease. Source of Funding: Dalhousie Medical Research Foundation © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1282 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Charlie Gillis More articles by this author Gabriela Ilie More articles by this author Cody MacDonald More articles by this author Ross Mason More articles by this author Ricardo Rendon More articles by this author Nikhilesh Patel More articles by this author David Bowes More articles by this author Greg Bailly More articles by this author David Bell More articles by this author Derek Wilke More articles by this author Robert Rutledge More articles by this author Expand All Advertisement PDF downloadLoading ...