Mp47-12 Correlation Between Comorbidities and the Response of Erectile Dysfunction (Ed) to Low-Intensity Extracorporeal Shock Wave Therapy (Li-Eswt): A Prospective Study

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy I (MP47)1 May 2024MP47-12 CORRELATION BETWEEN COMORBIDITIES AND THE RESPONSE OF ERECTILE DYSFUNCTION (ED) TO LOW-INTENSITY EXTRACORPOREAL SHOCK WAVE THERAPY (LI-ESWT): A PROSPECTIVE STUDY Luigi Quaresima, Daniela Fasanella, Luciana Mariani, and Willy Giannubilo Luigi QuaresimaLuigi Quaresima , Daniela FasanellaDaniela Fasanella , Luciana MarianiLuciana Mariani , and Willy GiannubiloWilly Giannubilo View All Author Informationhttps://doi.org/10.1097/01.JU.0001008880.11564.10.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Low-intensity extracorporeal shock wave therapy (LI-ESWT) has been used for the treatment of Erectile Dysfunction (ED), in particular for mild ED or for patients who are poorly responsive to oral therapy. Unfortunately, LI-ESWT, which consists of a cycle of treatments of at least 10 sessions, whose cost is at the patient's charge, is burdened by a failure rate that is far from negligible. The purpose of our study is to identify the factors that predispose to the response of LI-ESWT. METHODS: 115 patients with mild to moderate ED were treated from February 2021 to February 2023. All patients were stratified by age, BMI (normal weight, overweight, obese), and comorbidities (smoking, compensated or decompensated diabetes mellitus, controlled or not controlled hypertension) and were evaluated before and 2 weeks after the end of the course of treatment with questionnaire International Index of Erectile Function short version (IIEF-5). The study excluded patients who had previously performed unsuccessful drug therapy. Patients with iatrogenic or post-trauma ED were also excluded. The patients underwent a cycle of 10 sessions of focal LI-ESWT with an electro-pneumatic device with 1.1 Bar pressure with 4000 strokes per session with 4 Hz frequency. RESULTS: 115 patients with an average age of 63 years (56-70) met the study criteria. Of these, 71 showed an increase in the questionnaire score: these patients with an average pre-treatment IIEF-5 score of 19/25, had an average post-treatment IIEF-5 score of 22/25. The percentage of patients with a valid erection recovery was 61%. This percentage was lower in the subcategories of obese patients, smokers, with not well-compensated diabetes, with not well-controlled hypertension, with percentages of 11.3, 15.5, 12.7, and 11.3 % respectively (p0,05). CONCLUSIONS: Age, overweight (not obesity), well-compensated diabetes, or well-controlled hypertension do not affect the recovery of a valid erection with the LI-ESWT. On the contrary, smokers or patients with poorly controlled diabetes, not controlled hypertension, or with obesity show a less than average response to treatment and should be directed toward other therapies. Source of Funding: This study received no external funding © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e767 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Luigi Quaresima More articles by this author Daniela Fasanella More articles by this author Luciana Mariani More articles by this author Willy Giannubilo More articles by this author Expand All Advertisement PDF downloadLoading ...