Mp69-11 Androgen Receptor Signaling Induces Angiogenesis in Irradiated Bladder Cells

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney p=0.006) was an independent risk factor for GH. The levels of FLT1 and KDR expression were significantly higher in irradiated bladder cancer cells pretreated with DHT than in those with mock treatment. Furthermore, the effect of DHT on FLT1/KDR expression was abolished by an anti-androgen HF. Finally, the incidence rate of GH in RC model mice receiving castration was significantly lower than that in those receiving sham surgery. Correspondingly, MVD and VEGFR expression of bladders in those receiving castration were significantly lower than that in those receiving sham surgery. CONCLUSIONS: ADT through the peri-radiotherapy period has a potential for preventing RC. Our results suggest that AR activation contributes to inducing angiogenesis in irradiated bladder cells. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1123 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Takahiro Komori More articles by this author Hiroki Ide More articles by this author Fukada Junichi More articles by this author Kazuhiro Matsumoto More articles by this author Yuto Baba More articles by this author Akari Komatsuda More articles by this author Sotaro Kitaoka More articles by this author Chugo Nishimura More articles by this author Mototsugu Oya More articles by this author Hiroshi Miyamoto More articles by this author Expand All Advertisement PDF downloadLoading ...