Mp60-03 the Influence of Radiotherapy Before or After Radical Prostatectomy on Functional Outcome

You have accessJournal of UrologyProstate Cancer: Advanced (Including Drug Therapy) III (MP60)1 May 2024MP60-03 THE INFLUENCE OF RADIOTHERAPY BEFORE OR AFTER RADICAL PROSTATECTOMY ON FUNCTIONAL OUTCOME David Pfister, Constatnin Rieger, Christian Bach, and Axel Heidenreich David PfisterDavid Pfister , Constatnin RiegerConstatnin Rieger , Christian BachChristian Bach , and Axel HeidenreichAxel Heidenreich View All Author Informationhttps://doi.org/10.1097/01.JU.0001008804.84010.ec.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Patients with newly diagnosed prostate cancer can mostly choose between either radical prostatectomy or radiotherapy beside active surveillance in case of low risk disease. Continence rates are significantly lower in case of salvage radical prostatectomies for local recurrences after radiotherapy. To get a more detailled oversight of the impact of radiotherapy on functional outcome we analyzed patients with radiotherapy in different scenarios: salvage radiotherapy (sRT) after radical prostatectomy, salvage prostatectomy (sRPE), prostatectomy after radiotherapy for rectal cancer (RPERC) with patients with primary prostatectomy (pRPE). In addition quality of life was analyzed. METHODS: Retrospective analysis of patients undergoing pRPE, RPERC, sRPE and sRT. Continence and quality of life was collected pre- and posttreatment. Assessment of continence and quality of life by ICIQ-questionaire and question 30 from EORTC QLQ C30. RESULTS: 100, 102, 19 and 30 patients with pRPE, sRPE, RPERC and with SRT were analyzed. Median age at time of therapy was 71, 69, 76 and 63 years. The median ICIQ pre intervention was 0 for RPE and sRPE, 0.5 for sRT and 3.5 for RPERC. Posttreatment there was a significant difference in sRPE (median ICIQ 15.5) whereas incontinence rates in the other treatment groups was only moderate (median ICIQ: sRT 5.5, RPERC 5.0, pRPE 8.5). There was no change in quality of life in all groups. CONCLUSIONS: The most relevant change in continence rates was seen in patients with sRPE. Nevertheless this does not affect quality of life in this patient cohort. These data can be used as basis for discussing primary treatment especially in young patients highlighting potential consequences of salvage treatments on functional outcome. In patients with metachrone prostate cancer after multimodal treatment for rectal cancer radical prostatectomy can safely be offered without negative impact on functional outcome. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1000 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information David Pfister More articles by this author Constatnin Rieger More articles by this author Christian Bach More articles by this author Axel Heidenreich More articles by this author Expand All Advertisement PDF downloadLoading ...