Evaluation of Single/Multiple Joint Effects of Lipid Profiles on Hypertension, Diabetes Mellitus and Obesity Accompanying Coronary Artery Disease

Objective: Although cardiovascular diseases are among the most prominent causes of mortality/morbidity in the world, they are even more important together with comorbidities. This study aims to reveal the single/multiple effects of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride (TG) on hypertension (HT), type 2 diabetes mellitus (T2DM) and obesity accompanying coronary artery disease (CAD). Method: The data were retrospectively achieved from the records of CAD patients undergoing coronary bypass surgery at the Department of Cardiovascular Surgery, Medical Center, University. The medical knowledge discovery process (MKDP) was applied to the data concerning HT, DM, obesity, TC, HDL-C, LDL-C, and TG variables. Different methods were used to determine the optimal cut-off points of lipid profiles. Logistic regression analysis (LRA) was examined the single/multiple effects of lipid profiles on HT, T2DM, and obesity. Results: TC, LDL-C, TG, and HDL-C lipid profiles categorized according to the cut-off points determined in the current study were analyzed with LRA models. LDL-C (>117 mg/dL)*TC (>191 mg/dL)*HDL-C (>37.2 mg/dL) in HT and TC (>190 mg/dL)*TG (>197) mg/dL)*HDL-C (>36.3 mg/dL) in T2DM interaction terms had a moderate effect size. LDL-C (>115 mg/dL)*TG (>197 mg/dL)*HDL-C (>36.3 mg/dL) interaction terms in T2DM and TC (>192 mg/dL)*LDL-C (>117 mg/dL)*HDL-C (>36.8 mg/dL), TK (>192 mg/dL)*TG (>193 mg/dL)*HDL-C (>36.8 mg/dL) and LDL-C (>117 mg/dL)*TG (>193 mg/dL)*HDL-C (>36.8 mg/dL) interaction terms in obesity were reported as having a high effect size. Conclusion: In conclusion, it is recommended to use the approach that analyzes the cut-off points proposed in this study for lipid profiles in predicting HT, T2DM, and obesity.