A Study on the Bacteriological Profile of Uncomplicated Urinary Tract Infections in a Tertiary Care Hospital, K.A.P.V. Govt. Medical College, Trichy, India

This study was conducted to identify and isolate the bacterial pathogens causing uncomplicated urinary tract infections and their antimicrobial susceptibility patterns in a tertiary care hospital, Trichy. Clean catch midstream urine samples were collected from symptomatic patients and cultured under aerobic conditions on Cysteine Lactose Electrolyte Deficient (CLED) agar. Samples having significant growth (>10⁵ cfu /ml) and significant number of pus cells in direct smear were processed further by standard microbiological techniques. Antimicrobial susceptibility pattern was evaluated by Kirby – Bauer disk diffusion method according to CLSI guidelines. Out of 3408 urine samples processed, 663 samples showed significant growth on culture. The prevalence of UTI in study population was 20%. Escherichia coli was the commonest isolate (59. 8%), Klebsiella spp (18%), Enterococcus spp (15%), Acinetobacter baumanni (4%), Pseudomonas aeruginosa (3%), Proteus spp (0. 75%). Among these isolates gram negative bacilli showed high susceptibility to Nitrofurantoin, Cotrimoxazole and gram positive organisms to Nitrofurantoin and Ampicillin. This study has shown Nitrofurantoin, Cotrimoxazole and Ampicillin are the most effective drugs for the empirical therapy of UTI in our region. The study of antimicrobial susceptibility pattern of organisms causing UTI in particular area can help the clinicians to choose the antibiotic so that misuse of antibiotics can be prevented.