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Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule | Synapse

April 9, 2024Open Access

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Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

OWOlivia WegrzyniakUppsala University FLFrancesco LechiUppsala University BMBogdan MitranUppsala University

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Non-invasive assessment of fibrogenic activity, rather than fibrotic scars, could significantly improve the management of fibrotic diseases and the development of anti-fibrotic drugs. This study explores the potential of an Affibody molecule (Z09591) labeled with the Al(18)F-restrained complexing agent (RESCA) method as a tracer for the non-invasive detection of fibrogenic cells. Z09591 was functionalized with the RESCA chelator for direct labeling with [

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Wegrzyniak et al. (Tue,) studied this question.

synapsesocial.com/papers/68e6fca8b6db643587676732 https://doi.org/https://doi.org/10.1016/j.isci.2024.109688

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