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You have accessJournal of UrologyOriginal Research Articles1 May 2024Reply by Authorsis a reply to letterEditorial Comment Hongyang Qian, Chenfei Chi, Thibault Tricard, Yinjie Zhu, Liang Dong, Yanqing Wang, Jianjun Sha, Jiayi Wang, Zehua Ma, Yan Wang, Jiazhou Liu, Baijun Dong, Jiahua Pan, and Wei Xue Hongyang QianHongyang Qian , Chenfei ChiChenfei Chi , Thibault TricardThibault Tricard , Yinjie ZhuYinjie Zhu , Liang DongLiang Dong , Yanqing WangYanqing Wang , Jianjun ShaJianjun Sha , Jiayi WangJiayi Wang , Zehua MaZehua Ma , Yan WangYan Wang , Jiazhou LiuJiazhou Liu , Baijun DongBaijun Dong , Jiahua PanJiahua Pan , and Wei XueWei Xue View All Author Informationhttps://doi.org/10.1097/JU.0000000000003921AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail We express our sincere appreciation to Dr Stone and Dr Kibel for their editorial comment on our study.1 The effective management of locally advanced prostate cancer remains an area of growing exploration. Several prior studies have highlighted the potential benefits of docetaxel-based neoadjuvant chemohormonal therapy. However, the scarcity of large randomized controlled trials with clinically meaningful end points on chemohormonal therapy for locally advanced disease limits the availability of high-level evidence. Of note, high-risk, locally advanced prostate cancer represents a large heterogenous group, necessitating a comprehensive understanding and investigation of distinct subgroups and genetic factors in future trials. Additionally, given significant toxicity of chemotherapeutic approaches, careful consideration and thorough evaluation of eligible patients are imperative before implementation. The forthcoming exploration of novel hormonal agents in neoadjuvant treatment settings might also hold promise for further advancements in this field. REFERENCE 1. A prospective randomized trial of neoadjuvant chemohormonal therapy vs hormonal therapy in locally advanced prostate cancer treated by radical prostatectomy. J Urol. 2024; 211(5):648-655. Google Scholar © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsRelated articlesJournal of Urology14 Mar 2024Editorial Comment Volume 211Issue 5May 2024Page: 657-657 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Hongyang Qian More articles by this author Chenfei Chi More articles by this author Thibault Tricard More articles by this author Yinjie Zhu More articles by this author Liang Dong More articles by this author Yanqing Wang More articles by this author Jianjun Sha More articles by this author Jiayi Wang More articles by this author Zehua Ma More articles by this author Yan Wang More articles by this author Jiazhou Liu More articles by this author Baijun Dong More articles by this author Jiahua Pan More articles by this author Wei Xue More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...