Wcn24-2224 Association of Stem Cells and Renal Artery Revascularization Prevents Long Term Deterioration of Renal Function in Renovascular Hypertension Model in Rats

Stenosis of the renal artery causes renovascular hypertension (RVH) and chronic renal ischemia, resulting in kidney damage that can become irreversible. Clinical studies show that the restoration of renal blood flow is the most efficient therapy to normalize the blood pressure (BP) with significant benefits on renal function, however, the damage caused by chronic hypoxia is not fully reversed and renal function may progressively deteriorate over the time. Mesenchymal stem cells (MSC) have produced discreet results in minimizing RVH and improving renal structure and function in the experimental RVH model since the obstruction persists.