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The credibility revolution advances the use of research designs that permit identification and estimation of causal effects. However, understanding which mechanisms produce measured causal effects remains a challenge. A dominant current approach to the quantitative evaluation of mechanisms relies on the detection of heterogeneous treatment effects with respect to pre-treatment covariates. This paper develops a framework to understand when the existence of such heterogeneous treatment effects can support inferences about the activation of a mechanism. We show first that this design cannot provide evidence of mechanism activation without additional, generally implicit, assumptions. Further, even when these assumptions are satisfied, if a measured outcome is produced by a non-linear transformation of a directly-affected outcome of theoretical interest, heterogeneous treatment effects are not informative of mechanism activation. We provide novel guidance for interpretation and research design in light of these findings.
Fu et al. (Mon,) studied this question.
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