Optimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting

firstₚage Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Optimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting † by Madhumethra Ramasamy GovindarajMadhumethra Ramasamy Govindaraj SciProfiles Scilit Preprints. org Google Scholar *, Latha SubbiahLatha Subbiah SciProfiles Scilit Preprints. org Google Scholar and Selvamani PalanisamySelvamani Palanisamy SciProfiles Scilit Preprints. org Google Scholar Department of Pharmaceutical Technology, University College of Engineering Bharathidasan Institute of Technology Campus, Anna University, Tiruchirappalli 620024, Tamil Nadu, India * Author to whom correspondence should be addressed. † Presented at the 4th International Electronic Conference on Cancers, 6–8 March 2024; Available online: https: //sciforum. net/event/IECC2024. Proceedings 2024, 100 (1), 9; https: //doi. org/10. 3390/proceedings2024100009 Published: 27 March 2024 Download keyboardₐrrowdown Download PDF Download PDF with Cover Download XML Download Epub Versions Notes Keywords: targeted drug delivery; nanoliposomes; breast cancer; iron oxide nanoparticles; letrozole Background: Breast cancer is one of the most frequently diagnosed cancers and is the leading cause of death among women worldwide. Breast cancers are most common among women and they represent the second most common cancer condition. Moreover, breast cancers account for 14% of all cancers in women. The development of magnetic nanoliposomes as a carrier-loaded drug delivery system promotes the active-site-targeted delivery of drug molecules with increased biocompatibility and reduced toxicity and side-effects. Aim: The research work aims to develop and characterize magnetically letrozole nanoliposomes used for breast cancer targeting. Methodology: The thin film hydration method is carried out in preparation of letrozole nanoliposomes. Citric-acid-coated magnetic nanoparticles are synthesized via the chemical co-precipitation method. The formulated nanosuspension is characterized through initial characterization studies. Results: The characterization studies show that various physical, chemical, and morphological integrity of nanoliposomal suspension. In vitro characterization studies reported that the average hydrodynamic size of LET-MNLs was 89. 23 nm with a charge of −24 mV and apolydispersity index of 0. 395. The drug loading and encapsulation efficiency of the prepared formulation were studied at various stages to confirm the conjugation of letrozole with the magnetic nanoliposomal system, and the highest encapsulation efficiency was found to be 76. 83%. Conclusions: Liposomal nanocarriers promote targeted responses and iron oxide nanoparticles create an onsite action and lower the toxicity associated with unwanted biodistribution. Based on the results from pharmaceutical characterizations, the developed formulation is fit for targeted drug delivery applications. Further in vitro and in vivo studies will be carried out to assess the anticancer efficacy of developed formulation. Author ContributionsConceptualization, S. P. and L. S. ; methodology, L. S. ; software, S. P. ; validation, M. R. G. , L. S. and S. P. ; formal analysis, M. R. G. ; investigation, S. P. ; resources, S. P. ; data curation, M. R. G. ; writing—original draft preparation, M. R. G. ; writing—review and editing, S. P. ; visualization, S. P. ; supervision, L. S. ; project administration, L. S. All authors have read and agreed to the published version of the manuscript. FundingThis research received no external funding. Institutional Review Board StatementNot applicable. Informed Consent StatementNot applicable. Data Availability StatementData are contained within the article. Conflicts of InterestThe authors declare no conflict of interest. Disclaimer/Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author (s) and contributor (s) and not of MDPI and/or the editor (s). MDPI and/or the editor (s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https: //creativecommons. org/licenses/by/4. 0/). Share and Cite MDPI and ACS Style Govindaraj, M. R. ; Subbiah, L. ; Palanisamy, S. Optimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting. Proceedings 2024, 100, 9. https: //doi. org/10. 3390/proceedings2024100009 AMA Style Govindaraj MR, Subbiah L, Palanisamy S. Optimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting. Proceedings. 2024; 100 (1): 9. https: //doi. org/10. 3390/proceedings2024100009 Chicago/Turabian Style Govindaraj, Madhumethra Ramasamy, Latha Subbiah, and Selvamani Palanisamy. 2024. "Optimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting" Proceedings 100, no. 1: 9. https: //doi. org/10. 3390/proceedings2024100009 Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view.