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March 19, 2024Neurosurgery12 citationsOpen Access

Noninvasive Autopsy-Validated Tumor Probability Maps Identify Glioma Invasion Beyond Contrast Enhancement

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SBSamuel BobholzMedical College of WisconsinALAllison LowmanMedical College of WisconsinJCJennifer ConnellyMedical College of Wisconsin

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Abstract

This study identified a clinically significant subset of patients with glioma with tumor outside of contrast enhancement present at autopsy and subsequently developed a method for detecting nonenhancing tumor using radio-pathomic mapping. We tested the hypothesis that autopsy-based radio-pathomic tumor probability maps would be able to noninvasively identify areas of infiltrative tumor beyond traditional imaging signatures.

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Bobholz et al. (2024) studied this question.

synapsesocial.com/papers/68e73509b6db6435876af005https://doi.org/10.1227/neu.0000000000002898
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