Histopathological Study of Prostatic Lesions in Transurethral Resection of Prostate Specimens in Correlation with Serum Prostate Specific Antigen Levels

Background: Diseases of prostate are very common among elderly males and Benign Prostatic Hyperplasia (BPH) is the commonest. Prostate Specific Antigen (PSA) level estimation has become a popular method for screening prostatic lesions. This study was carried out to evaluate the histopathological findings of prostatic lesions and to see the correlation with serum prostate specific antigens. Materials and Methods: Permission was taken from Institutional Review Committee (IRC) of National Medical College before starting the study (Ref. F-NMC/641/079-080). Transurethral Resection of Prostate (TURP) specimens received for histopathological examination in the Department of Pathology from March 2023 to December 2023 were included in the study. Paraffin embedded sections were stained with routine haematoxylin and eosin stain. The PSA levels were recorded before the surgical procedure. Serum PSA level was estimated using chemiluminescent assay. Serum PSA levels were arbitrarily divided into 0 – 4 ng/ml, 4.1 – 10 ng/ml, 10.1 – 20 ng/ml, 20.1 – 30 ng/ml. and > 30 ng/ml. Results: Total Transurethral Resection of Prostate (TURP) specimens received were 60. With 78.3%, benign prostatic hyperplasia was the most common followed by prostatic intraepithelial lesion in 11.7%. and malignancy (prostatic adenocarcinoma) in 10%. PSA levels were increased in prostatic intraepithelial neoplasms and malignancies. Conclusion: PSA is an important marker for prostatic lesions. It is normal to mildly increase in benign conditions (eg. BPH) and markedly increased in malignancies. Key words: Benign Prostatic Hyperplasia, Adenocarcinoma prostate, Serum prostate specific antigens, Total Transurethral Resection of Prostate.